cytoplasmic FMR1-interacting protein 1 (specifically Rac1-associated protein 1, Sra-1, p140sra-1, CYFIP1, KIAA0068)

Function: 1) role in formation of membrane ruffles & lamellipodia protrusions & in axon outgrowth 2) binds to F-actin but not to RNA 3) interacts with the active GTP-bound form of RAC1 4) interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2 5) component of the WAVE2 complex 6) interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2, necessary for DPYSL2-induced axon outgrowth Structure: - belongs to the CYFIP family Compartment: - cytoplasm, perinuclear region - cell projection, lamellipodium, ruffle - synaptosome - highly expressed in the perinuclear region - enriched in synaptosomes, membrane ruffles & at the tips of lamellipodia Alternative splicing: named isoforms=3

Properties

SIZE: MW = 145 kD entity length = 1253 aa COMPARTMENT: cytoplasm

Database Correlations

OMIM 606322 UniProt Q7L576 Pfam PF05994

References

UniProt :accession Q7L576