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cytokine receptor-like factor 1 (cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1, ZCYTOR5, UNQ288/PRO327)
Function:
1) cytokine receptor subunit
2) regulatory role in the immune system
3) fetal development, nervous system development (putative)
4) forms covalently linked dimers & tetramers
5) component of CRLF1-CLCF1 complex
6) induced by IFN-gamma, TNF-alpha, IL-6 in fibrobasts
7) WSXWS essential for folding, transport, receptor binding
8) has 2 fibronectin F3 modules
Compartment: secreted
Expression:
- expressed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid, ovary, fetal lung
Pathology:
- defects in CRLF1 result in cold-induced sweating syndrome 1 (CISS1)
Related
cold-induced sweating syndrome (CISS)
General
glycoprotein
secreted protein
Properties
SIZE: MW = 46 kD
entity length = 422 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-37}
immunoglobulin superfamily domain {38-131}
MOTIF: N-glycosylation site {N92}
N-glycosylation site {N104}
fibronectin type III domain or F3 module {134-229}
MOTIF: N-glycosylation site {N140}
cysteine residue {C143}
MODIFICATION: cysteine residue {C153}
cysteine residue {C153}
MODIFICATION: cysteine residue {C143}
N-glycosylation site {N168}
cysteine residue {C184}
MODIFICATION: cysteine residue {C195}
cysteine residue {C195}
MODIFICATION: cysteine residue {C184}
Ser phosphorylation site {S219}
fibronectin type III domain or F3 module {234-334}
MOTIF: N-glycosylation site {N292}
WSXWS motif {327-331}
N-glycosylation site {N382}
Database Correlations
OMIM correlations
MORBIDMAP 604237
UniProt O75462
Pfam PF00041
References
UniProt :accession O75462
Component-of
CRLF1/CLCF1 complex