cytokine receptor

This superfamily of receptors conveys their signals through interactions with Janus kinases. Binding of cytokine to receptor induces oligomerization of receptor & enhances affinity of cyto- plasmic domain for Janus kinase. Cytokine receptors may also directly stimulate src family of tyrosine kinases.

Specific

AI2CA AI2CB CDw119; interferon-gamma receptor alpha chain; IFN-gamma-R1; CD119 (IFNGR1) CDw131; cytokine receptor common subunit beta; KH97; GM-CSF/IL-3/IL-5 receptor common beta-chain; CDw131; CD131 (CSF2RB, IL3RB, IL5RB) chemokine receptor (chemoattractant receptor) ciliary neurotrophic factor [CNTF] receptor colony-stimulating factor [CSF] receptor erythropoietin receptor; EPO-R (EPOR) interferon receptor interleukin receptor leptin receptor; LEP-R; OB receptor; OB-R; HuB219; CD295 (LEPR, DB, OBR) leukemia inhibitory factor [LIF] receptor or oncostatin M [Osm] receptor tgf beta receptor superfamily thrombopoietin receptor; TPO-R; myeloproliferative leukemia protein; C-mpl; CD110 (MPL, TPOR) transforming growth factor [TGF] receptor

General

cell surface receptor metabotropic receptor phosphoprotein

Properties

COMPARTMENT: plasma membrane MOTIF: cysteine residue ligand-binding site transmembrane domain box1 motif FOR-BINDING-OF: Janus kinase (JAK) box2 motif FOR-BINDING-OF: Janus kinase (JAK) Tyr phosphorylation site

References

- Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: 8048164