Search
cytokine
Cytokines are secreted peptides/proteins functioning as intercellular messengers. Cytokines may be distinguished from classical hormones in several ways. The are normally made by more than one cell, have a wide range of overlapping biological activities, & generally act over a short range. Most mammalian cells seem to be able to produce a range of cytokines & to respond to various cytokines through surface receptors.
Related
cytokine receptor
Specific
adipokine
bone morphogenetic protein (BMP)
chemokine; chemoattractant
chemotactic cytokine CP10
ciliary neurotrophic factor; CNTF (CNTF)
embryonic growth/differentiation factor 1; GDF-1 (GDF1)
epidermal growth factor (EGF)/urogastrone
fibroblast growth factor
G26 T-cell secreted protein
gremlin-1 (cysteine knot superfamily 1 BMP antagonist 1, increased in high glucose protein 2, IHG-2, down-regulated in Mos-transformed cells protein, proliferation-inducing gene 2 protein, GREM1, CKTSF1B1, DAND2, DRM, PIG2)
gremlin-2 (cysteine knot superfamily 1 BMP antagonist 2, protein related to DAN & cerberus, GREM2, CKTSF1B2, DAND3, PRDC)
hematopoietic cell growth factor
IL-1 receptor accessory protein (IL-1 receptor accessory protein, IL-1RAcP, IL1RAP)
interferon
interleukin
interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA)
leukemia inhibitory factor; melanoma-derived LPL inhibitor; differentiation-stimulating factor; D factor,; HILDA; MLPLI; emfilermin (LIF)
leukocyte cell derived chemotaxin (lect)
lymphokine
macrophage migration inhibitory factor; MIF; glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase (MIF, GLIF, MMIF)
monokine
neuropoietin
nodal homolog (NODAL)
oncostatin-M (OSM)
platelet-derived growth factor (PDGF)
sis-epsilon or p500
stem cell factor; mast-cell growth factor; c-kit ligand; steel homolog (SCF, KITLG, MGF)
thrombopoietin; megakaryocyte colony stimulating factor; C-MPL ligand; megakaryocyte growth & development factor (MGDF, THPO)
transforming growth factor [TGF]-beta
tumor necrosis factor (TNF) family protein
General
growth factor
secreted peptide
secreted protein
Properties
COMPARTMENT: extracellular compartment
Database Correlations
Kegg hsa/hsa04060
References
- Henderson & Bake TIPS 13:145 1993
- Schaible HG, von Banchet GS, Boettger MK et al
The role of proinflammatory cytokines in the generation and
maintenance of joint pain.
Ann N Y Acad Sci. 2010 Apr;1193:60-9.
PMID: 20398009