cytochrome P450 51; sterol 14-alpha demethylase; lanosterol 14-alpha demethylase (CYPL1, P450L1, LDM, P450-14DM)

Function: 1) involved in cholesterol biosynthesis 2) catalyzes C14-demethylation of lanosterol 3) transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24- triene-3-beta-ol Structure: belongs to the cytochrome P450 family Compartment: microsome (putative) Expression: - ubiquitously expressed - highest levels in testis, ovary, adrenal, prostrate, liver, kidney & lung

General

cytochrome P450 demethylase membrane protein

Properties

SIZE: MW = 57 kD entity length = 503 aa COMPARTMENT: smooth endoplasmic reticulum MOTIF: transmembrane domain {24-44} active site Iron [Fe]-binding site SITE: 449-449

Database Correlations

OMIM 601637 UniProt Q16850 Pfam PF00067 Entrez Gene 1595 Kegg hsa:1595 ENZYME 1.14.13.70

References

UniProt :accession Q16850