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cytochrome P450 2D7 (CYP2D7)
Function:
- may be responsible for the metabolism of many drugs & environmental chemicals that it oxidizes
- conflicting reports on role in metabolism of codeine to morphine [2,3]
RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O
Cofactor: heme
Structure:
- belongs to the cytochrome P450 family
Compartment:
- membrane
- multi-pass membrane protein
- mitochondrion
Expression:
- expressed in brain cortex (at protein level)
Polymorphism:
- conflicting reports of a rare double polymorphism giving rise to expression of a functional protein [2,4,5]
Note: could be the product of a pseudogene
General
glycoprotein
transmembrane 2e protein
Properties
SIZE: entity length = 515 aa
MW = 57 kD
COMPARTMENT: mitochondria
cytoplasm
MOTIF: exoplasmic domain {1-2}
transmembrane domain {3-23}
cytoplasmic loop {24-301}
transmembrane domain {302-322}
exoplasmic domain {323-515}
MOTIF: N-glycosylation site {N416}
Iron [Fe]-binding site
SITE: 461-461
Database Correlations
UniProt A0A087X1C5
Pfam PF00067
ENZYME 1.14.14.1
References
- UniProt :accession A0A087X1C5
- PMID: 15051713
- PMID: 18838503
- PMID: 16169517
- PMID: 17494644