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cytochrome c oxidase (complex IV)
Complex IV of mitochondrial electron transport.
Laboratory:
- cytochrome C oxidase in leukocytes
- cytochrome C oxidase/citrate synthase in tissue
Interactions
molecular events
Related
cytochrome C oxidase deficiency; mitochondrial complex IV deficiency; COX deficiency
electron transport
General
cytochrome oxidase
metalloprotein
mitochondrial membrane protein
multienzyme complex
Properties
SIZE: MW = 200 kD
COMPARTMENT: inner mitochondrial membrane
MOTIF: membrane region
active site
copper [Cu]-binding site
EFFECTOR-BOUND: Cu+2
MOTIF: histidine residue (3)
Database Correlations
OMIM 123870
ENZYME 1.9.3.1
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 605
- OMIM :accession 123870
- Loinc
Components
cytochrome a
cytochrome a3
cytochrome c oxidase subunit 10
cytochrome c oxidase subunit 1; cytochrome c oxidase polypeptide I (MT-CO1 COI COXI MTCO1)
cytochrome c oxidase subunit 2; cytochrome c oxidase polypeptide II (MT-CO2, COII, COXII, MTCO2)
cytochrome c oxidase subunit 3; cytochrome c oxidase polypeptide III (MT-CO3 COIII COXIII MTCO3)
cytochrome c oxidase subunit 4 isoform 1, mitochondrial; cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit IV isoform 1; COX IV-1 (COX4I1, COX4)
cytochrome c oxidase subunit 5
cytochrome c oxidase subunit 6
cytochrome c oxidase subunit 7
cytochrome c oxidase subunit 7A-related protein, mitochondrial; cytochrome c oxidase subunit VIIa-related protein; COX7a-related protein; EB1 (COX7A2L, COX7AR, COX7RP)
cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase polypeptide VIII-liver/heart; cytochrome c oxidase subunit 8-2 (COX8A, COX8, COX8L)
cytochrome c oxidase subunit 9