cytochrome C heme lyase; holocytochrome c synthase (HCCS, CCHL)

Function: - links covalently the heme group to the apoprotein of cytochrome c (putative) holocytochrome c apocytochrome c + heme Structure: - belongs to the cytochrome c-type heme lyase family - contains 2 HRM (heme regulatory motif) repeats Compartment: mitochondrial inner membrane (putative) Pathology: - defects in HCCS are a cause of syndromic microphthalmia 7

General

lyase mitochondrial protein

Properties

SIZE: entity length = 268 aa MW = 31 kD COMPARTMENT: mitochondria MOTIF: consensus repeat {24-29} SEQUENCE-IS: HRM consensus repeat {34-39} SEQUENCE-IS: HRM domain {CENTRAL-REGION} MOTIF: histidine residue tryptophan residue HOMOLOGY: cytochrome C heme lyase cytochrome C1 heme lyase domain {C-TERMINAL} MOTIF: histidine residue tryptophan residue HOMOLOGY: cytochrome C heme lyase cytochrome C1 heme lyase

Database Correlations

OMIM correlations UniProt P53701 Pfam PF01265 ENZYME 4.4.1.17

References

UniProt :accession P53701