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cytochrome b ascorbate-dependent protein 3; cytochrome b561 family member A3; lysosomal cytochrome b; Lcytb (CYB561A3, CYBASC3, LCYTB, PSEC0259)
Function:
- ferric-chelate reductase that reduces Fe+3 to Fe+2 before its transport from the endosome to the cytoplasm
- probably uses ascorbate as electron donor (putative)
Cofactor: binds 2 heme groups non-covalently (putative)
Structure:
- N-glycosylated (putative)
- contains 1 cytochrome b561 domain
Compartment: late endosome, lysosome membrane
Alternative splicing: named isoforms=2
General
glycoprotein
oxidoreductase
transmembrane 6 protein
Properties
SIZE: entity length = 242 aa
MW = 27 kD
COMPARTMENT: lysosome
MOTIF: transmembrane domain {8-28}
N-glycosylation site {N38}
transmembrane domain {46-66}
Iron [Fe]-binding site
SITE: 47-47
Iron [Fe]-binding site
SITE: 83-83
transmembrane domain {84-104}
Iron [Fe]-binding site
SITE: 87-87
Iron [Fe]-binding site
SITE: 105-105
Iron [Fe]-binding site
SITE: 117-117
transmembrane domain {120-140}
transmembrane domain {155-175}
Iron [Fe]-binding site
SITE: 156-156
transmembrane domain {203-223}
Database Correlations
UniProt Q8NBI2
Pfam PF03188
Entrez Gene 220002
Kegg hsa:220002
References
UniProt :accession Q8NBI2