cysteinyl leukotriene receptor 2 (CysLTR2, PSEC0146, HG57, HPN321, hGPCR21)

Function: - receptor for cysteinyl leukotrienes - G-protein-linked IP3-Ca⁺² second messenger system. - agonist induce: a) contractions of pulmonary veins b) relaxation of the pulmonary vascular endothelium - affinities: LTC4 = LTD4 >> LTE4 Structure: belongs to the G-protein coupled receptor 1 family Expression: - widely expressed - highest levels in the heart, placenta, spleen, peripheral blood leukocytes & adrenal gland - in lung, expressed in the interstitial macrophages, & slightly in smooth muscle cells

General

glycoprotein leukotriene receptor G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 40 kD entity length = 346 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-42} MOTIF: N-glycosylation site {N20} N-glycosylation site {N26} N-glycosylation site {N30} transmembrane domain {43-63} cytoplasmic loop {64-72} transmembrane domain {73-93} exoplasmic loop {94-123} MOTIF: cysteine residue {C111} MODIFICATION: cysteine residue {C187} transmembrane domain {124-144} cytoplasmic loop {145-153} transmembrane domain {154-174} exoplasmic loop {175-204} MOTIF: N-glycosylation site {N181} cysteine residue {C187} MODIFICATION: cysteine residue {C111} transmembrane domain {205-225} cytoplasmic loop {226-245} transmembrane domain {246-266} exoplasmic loop {267-286} transmembrane domain {287-307} cytoplasmic domain {308-346}

Database Correlations

OMIM 605666 UniProt Q9NS75 Pfam PF00001 Kegg hsa:5710

References

UniProt :accession Q9NS75