cysteine-rich with EGF-like domain protein 2 (CRELD2)

Function: 1) regulates transport of alpha4-beta2 neuronal nicotinic receptor (putative) 2) interacts with CHRNA4 Compartment: - secreted (putative), localizes to endoplasmic reticulum Alternative splicing: named isoforms=6 Expression: - ubiquitously expressed - expressed in all fetal tissues tested Structure: 1) belongs to the CRELD family 2) contains 2 EGF-like domains - contains 2 FU repeats (furin-like repeats)

General

glycoprotein secreted protein

Properties

SIZE: MW = 38 kD entity length = 353 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-24} EGF domain {136-178} MOTIF: cysteine residue {C140} MODIFICATION: cysteine residue {C154} cysteine residue {C148} MODIFICATION: cysteine residue {C166} cysteine residue {C154} MODIFICATION: cysteine residue {C140} cysteine residue {C166} MODIFICATION: cysteine residue {C148} cysteine residue {C168} MODIFICATION: cysteine residue {C177} cysteine residue {C177} MODIFICATION: cysteine residue {C168} FU {193-240} N-glycosylation site {N251} FU {253-302} EGF domain {290-331} MOTIF: cysteine residue {C294} MODIFICATION: cysteine residue {C308} cysteine residue {C301} MODIFICATION: cysteine residue {C317} cysteine residue {C308} MODIFICATION: cysteine residue {C294} cysteine residue {C317} MODIFICATION: cysteine residue {C301} cysteine residue {C319} MODIFICATION: cysteine residue {C330} cysteine residue {C330} MODIFICATION: cysteine residue {C319}

Database Correlations

OMIM 607171 UniProt Q6UXH1 Pfam PF07645

References

UniProt :accession Q6UXH1