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protein CYR61; CCN family member 1; cysteine-rich angiogenic inducer 61; insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; protein GIG1 (CYR61, CCN1, GIG1, IGFBP10)
Function:
- promotes cell proliferation, chemotaxis, angiogenesis & cell adhesion
- appears to play a role in wound healing by up-regulating, in skin fibroblasts, expression of a number of genes involved in angiogenesis, inflammation & matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 & integrins, integrin alpha-3 & integrin alpha-5
- CYR61-mediated gene regulation is dependent on heparin-binding
- down-regulates expression of collagen type-1 subunits COL1A1 & COL1A2
- promotes cell adhesion & adhesive signaling through integrin alpha-6/beta-1
- promotes cell migration through integrin alpha-v/beta-5
- promotes cell proliferation through integrin alpha-v/beta-3
- interaction with integrins is heparin- & cell-type-dependent & promotes cell adhesion
- in skin fibroblasts, binds ITGA6/ITGB1
- in endothelial cells, binds ITGAV/ITGB3
- in platelets, binds ITGA2B/ITGB3
- in vitro, binds ITGAV/ITGB5
Structure:
- belongs to the CCN family
- contains 1 CTCK (C-terminal cystine knot-like) domain
- contains 1 IGFBP N-terminal domain
- contains 1 TSP type-1 domain
- contains 1 VWFC domain
Compartment: secreted
General
secreted protein
Properties
SIZE: entity length = 381 aa
MW = 42 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
IGFBP N-terminal {25-94}
VWFC domain {98-164}
TSP1 module {228-273}
binding site
SITE: 279-315
FOR-BINDING-OF: heparin
C-terminal cystine knot {286-360}
MOTIF: cysteine residue {C286}
MODIFICATION: cysteine residue {C323}
cysteine residue {C303}
MODIFICATION: cysteine residue {C337}
cysteine residue {C314}
MODIFICATION: cysteine residue {C353}
cysteine residue {C317}
MODIFICATION: cysteine residue {C355}
cysteine residue {C322}
MODIFICATION: cysteine residue {C359}
cysteine residue {C323}
MODIFICATION: cysteine residue {C286}
cysteine residue {C337}
MODIFICATION: cysteine residue {C303}
cysteine residue {C353}
MODIFICATION: cysteine residue {C314}
cysteine residue {C355}
MODIFICATION: cysteine residue {C317}
cysteine residue {C359}
MODIFICATION: cysteine residue {C322}
Database Correlations
OMIM 602369
UniProt O00622
PFAM correlations
Entrez Gene 3491
Kegg hsa:3491
References
- UniProt :accession O00622
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cyr61/