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cysteine-rich motor neuron 2 protein (CRIM-2, cysteine-rich BMP regulator 2, Kielin/chordin-like protein 1, CRIM2, KCP1, KCP)
Function:
- enhances bone morphogenetic proteins (BMPs) signaling in a paracrine manner
- in contrast, it inhibits both activin-A & TGF-beta-1-mediated signaling pathway (putative)
- interacts with BMP7 &, by doing so, enhances binding to the type 1 receptors that contain cytoplasmic serine/threonine protein kinase domains
- able to interact with activin-A & TGF-beta 1 (putative)
Structure: contains 11 VWFC domains
Compartment: secreted (putative)
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 814 aa
MW = 87 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
coiled coil {56-88}
VWFC domain {136-189}
VWFC domain {190-249}
VWFC domain {250-308}
VWFC domain {309-366}
MOTIF: N-glycosylation site {N336}
VWFC domain {367-425}
VWFC domain {426-481}
VWFC domain {482-540}
VWFC domain {541-598}
VWFC domain {599-657}
VWFC domain {663-721}
VWFC domain {722-778}
Database Correlations
UniProt Q6ZWJ8
Pfam PF00093
References
UniProt :accession Q6ZWJ8