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cysteine-rich motor neuron 1 protein (CRIM-1, cysteine-rich repeat-containing protein S52, CRIM1)
Function:
1) role in CNS development by interacting with growth factors implicated in motor neuron differentiation & survival (putative)
2) role in capillary formation & maintenance during angiogenesis (putative)
3) modulates BMP activity by affecting its processing & delivery to the cell surface
4) interacts with BMP4 & BMP7
Structure:
- N-glycosylated
- contains 4 antistasin-like domains
- contains 1 IGFBP domain
- contains 6 VWFC domains
Compartment: cell membrane, secreted
Expression:
- expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver & small intestine
- expressed in blood vessels (at protein level)
General
glycoprotein
membrane protein
Properties
SIZE: MW = 114 kD
entity length = 1036 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-34}
IGFBP {37-95}
MOTIF: N-glycosylation site {N71}
N-glycosylation site {N113}
Cell attachment site {314-316}
N-glycosylation site {N330}
VWFC domain {334-391}
VWFC domain {401-457}
Antistasin-like 1 {469-498}
MOTIF: N-glycosylation site {N474}
Antistasin-like 2 {505-532}
Antistasin-like 3 {539-564}
Antistasin-like 4 {567-592}
VWFC domain {606-663}
VWFC domain {677-735}
N-glycosylation site {N746}
VWFC domain {751-809}
VWFC domain {817-874}
transmembrane domain {940-960}
Database Correlations
OMIM 606189
UniProt Q9NZV1
PFAM correlations
References
UniProt :accession Q9NZV1