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cystatin M (cystatin-E, cystatin-6, CST6)
Function:
- moderate inhibition of cathepsin B
- not active against cathepsin C
- substrate for transglutaminases
- acts as an acyl acceptor but not as an acyl donor
Structure: belongs to the cystatin family
Compartment: secreted
Expression:
- restricted to the stratum granulosum of normal skin & the secretory coils of eccrine sweat glands
- low expression levels are found in the nasal cavity
Pathology:
- restricted to the stratum granulosum/spinosum of psoriatic skin
General
cystatin
Properties
SIZE: entity length = 149 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-28}
glycine residue {36}
Secondary area of contact {80-84}
cysteine residue {C98}
MODIFICATION: cysteine residue {C113}
cysteine residue {C113}
MODIFICATION: cysteine residue {C98}
cysteine residue {C126}
MODIFICATION: cysteine residue {C146}
N-glycosylation site {N137}
cysteine residue {C146}
MODIFICATION: cysteine residue {C126}
INHIBITS: cysteine proteinase
Database Correlations
OMIM 601891
UniProt Q15828
Pfam PF00031
Entrez Gene 1474
Kegg hsa:1474
References
UniProt :accession Q15828