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cystatin 7, cystatin-F, leukostatin or cystatin-like metastasis-associated protein (CMAP)
Function:
- inhibits papain & cathepsin L, but with affinities lower than other cystatins
- may play a role in immune regulation through inhibition of a unique target in the hematopoietic system
Structure:
- homodimer, disulfide-linked
- belongs to the cystatin family
Compartment: secreted, cytoplasm
Expression:
- primarily expressed in peripheral blood cells & spleen
General
cystatin
Properties
SIZE: entity length = 145 aa
MW = 16 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-19}
cysteine residue {C26}
MODIFICATION: cysteine residue {C63}
glycine residue {37}
N-glycosylation site {N62}
cysteine residue {C63}
MODIFICATION: cysteine residue {C26}
Secondary area of contact {81-85}
cysteine residue {C99}
MODIFICATION: cysteine residue {C110}
cysteine residue {C110}
MODIFICATION: cysteine residue {C99}
N-glycosylation site {N115}
cysteine residue {C124}
MODIFICATION: cysteine residue {C144}
cysteine residue {C144}
MODIFICATION: cysteine residue {C124}
INHIBITS: cysteine proteinase
Database Correlations
OMIM 603253
UniProt O76096
Pfam PF00031
Entrez Gene 8530
Kegg hsa:8530
References
UniProt :accession O76096