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cystatin 5 (cystatin-D, CST5)
Function:
- cysteine proteinase inhibitor
- possibly plays a protective role against proteinases present in the oral cavity
Structure: belongs to the cystatin family
Compartment: secreted
Expression:
- expressed in parotid gland
- not expressed in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder
General
cystatin
Properties
SIZE: entity length = 142 aa
MW = 16 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
glycine residue {32}
Secondary area of contact {70-74}
cysteine residue {C95}
MODIFICATION: cysteine residue {C105}
cysteine residue {C105}
MODIFICATION: cysteine residue {C95}
cysteine residue {C119}
MODIFICATION: cysteine residue {C139}
cysteine residue {C139}
MODIFICATION: cysteine residue {C119}
INHIBITS: cysteine proteinase
Database Correlations
OMIM 123858
UniProt P28325
Pfam PF00031
Entrez Gene 1473
Kegg hsa:1473
References
UniProt :accession P28325