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cystatin-9 (cystatin-like molecule, CST9, CLM)
Function:
- may play a role in hematopoietic differentiation
- may play a role in inflammation
Structure: belongs to the cystatin family
Compartment:
- secreted
- may be targeted through the Golgi via the secretory pathway
Expression:
- expressed in heart, placenta, lung, liver, skeletal muscle & pancreas
- not expressed in brain
- up-regulated by LPS
Pathology:
- barely expressed in most tumor cell lines, but upregulated in some cancer cells, inlcuding
a) breast adenocarcinoma MCF-7 cells & U251 cells
b) promyelocytic leukemia cells (HL-60) or
c) myelomonocytic leukemia cells (U-937)
General
secreted protein
Properties
SIZE: entity length = 159 aa
MW = 18 kD
COMPARTMENT: golgi
MOTIF: signal sequence {1-28}
Database Correlations
UniProt Q5W186
Entrez Gene 128822
References
UniProt :accession Q5W186