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cystatin 8 (cystatin-related epididymal spermatogenic protein, CST8, CRES)
Function:
- performs a specialized role during sperm development & maturation
Structure: belongs to the cystatin family
Compartment: secreted
Expression:
- proximal caput region of the epididymis
- lower expression in the testis
- within the testis, localized to elongating spermatids
- within the epididymis, synthesized by the proximal caput epithelium
General
cystatin
Properties
SIZE: entity length = 142 aa
MW = 16 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
N-glycosylation site {N27}
N-glycosylation site {N39}
Secondary area of contact {77-81}
cysteine residue {C95}
MODIFICATION: cysteine residue {C105}
cysteine residue {C105}
MODIFICATION: cysteine residue {C95}
cysteine residue {C119}
MODIFICATION: cysteine residue {C139}
cysteine residue {C139}
MODIFICATION: cysteine residue {C119}
INHIBITS: cysteine proteinase
Database Correlations
OMIM 608683
UniProt O60676
Pfam PF00031
Entrez Gene 10047
Kegg hsa:1004
References
UniProt :accession O60676