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cystatin 11 (CST11, CST8L)
Function:
- antibacterial activity against the Gram-negative bacteria E. coli
- may play a role in sperm maturation & fertilization
Structure: belongs to the cystatin family
Compartment:
- nucleus, cytoplasm
- nuclear & cytoplasmic in the epididymis
- localized to the postacrosomal & tail regions of sperm
- probably localized to the outer surface of sperm
Alternative splicing: named isoforms=2
Expression:
- detected in the epithelium & lumen of the epididymis, & in sperm (at protein level)
General
cystatin
Properties
SIZE: entity length = 138 aa
MW = 17 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: signal sequence {1-26}
Secondary area of contact {76-80}
cysteine residue {C94}
MODIFICATION: cysteine residue {C102}
cysteine residue {C102}
MODIFICATION: cysteine residue {C94}
cysteine residue {C115}
MODIFICATION: cysteine residue {C135}
N-glycosylation site {N132}
cysteine residue {C135}
MODIFICATION: cysteine residue {C115}
INHIBITS: cysteine proteinase
Database Correlations
UniProt Q9H112
Pfam PF00031
Entrez Gene 140880
References
UniProt :accession Q9H112