cyclopentolate/phenylephrine (Cyclomydril)

Indications: - induction of mydriasis & cycloplegia in diagnostic procedures Contraindications: glaucoma Pharmacokinetics: 1) maximal mydirasis & cycloplegia in 15-60 minutes 2) usual duration of action 24 hours Dosage: 1) 1 drop every 5-10 minutes 2) do NOT exceed 3 times 3) apply finger pressure to lacrimal sac during & 1-2 minutes following application for medication to reduce frequency of systemic side effects Adverse effects: 1) burning senstation (frequent) 2) blurred vision 3) sensitivity to light 4) local irritation 5) increased intraocular pressure Mechanism of action: 1) cyclopentolate blocks action of acetylcholine 2) phenylephrine stimulates alpha-1 receptors

References

Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary

Components

cyclopentolate (Cyclogyl) phenylephrine (Neo-Synephrine, Mydrifin, sudafed PE, PE)