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cyclin T1 (CCNT1)
Function:
1) regulatory subunit of CDK9/cyclin T) complex
2) transition from abortive to production elongation by phosphorylating the CTD of RNA pol 2 large subunit
3) binds to transactivation domain of the HIV-1 nuclear transcriptional activator
4) cofactor for HIV 2-Tat & simian immunodeficiency virus
5) predominant cyclin associated with CDK9
Compartment: nucleus
Expression: ubiquitously expressed
General
cyclin T (positive transcription elongation factor B, P-TEFB)
Properties
SIZE: MW = 81 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G1
MOTIF: cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
coiled coil {379-430}
PEST region
SITE: 709-726
Database Correlations
OMIM 602506
UniProt O60563
Entrez Gene 904
References
- Wei P, Garber ME, Fang SM, Fischer WH, Jones KA.
A novel CDK9-associated C-type cyclin interacts directly with
HIV-1 Tat and mediates its high-affinity, loop-specific binding
to TAR RNA.
Cell. 1998 Feb 20;92(4):451-62.
PMID: 9491887
- UniProt :accession O60563
Component-of
7SK SNRNP complex