cyclin K (CCNK, CPR4)

Function: 1) transcriptional regulation 2) associated with phosphorylation of a) RNA polymerase 2 C-terminal domain b) CDK2 3) binds to CDK9 Structure: belongs to the cyclin family, cyclin C subfamily Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - highest levels in testis

Related

cyclin-dependent kinase-2 (CDK2) RNA polymerase-2

General

cyclin phosphoprotein

Properties

SIZE: MW = 41 kD entity length = 357 aa COMPARTMENT: cell nucleus CELL-CYCLE: G1 MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin cyclin box FOR-BINDING-OF: cyclin-dependent kinase glutamine-rich region {312-315} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S324} Ser phosphorylation site {S329}

Database Correlations

OMIM 603544 UniProt O75909 Entrez Gene 8812