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cyclin-I (CCNI)
Structure: belongs to the cyclin family
Expression:
- highest levels in adult heart, brain & skeletal muscle
- lower levels in adult placenta, lung, kidney & pancreas
- abundant in testis & thyroid
- high levels in fetal brain
- lower levels in fetal lung, liver & kidney
- expression is independent of the cell cycle in lung fibroblasts
General
cyclin
Properties
SIZE: entity length = 377 aa
MW = 43 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G1
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
Database Correlations
UniProt Q14094
Pfam PF00134
Entrez Gene 10983
Kegg hsa:10983
References
- UniProt :accession Q14094
- NIEHS-SNPs
http://egp.gs.washington.edu/data/ccni/