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cyclin C (CCNC, hSRB11)
Function:
- component of the mediator complex
- binds to & activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase 2 (RNAp II), which may inhibit formation of a transcription initiation complex
- cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase 2
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the cyclin family, cyclin C subfamily
- contains 1 cyclin N-terminal domain
Compartment: nucleus (probable)
Expression:
- G1/S-specific cyclin C
- maximum concentrations of cyclin C are observed in late G1
- highest levels in pancreas
- high levels in heart, liver, skeletal muscle & kidney
- low levels in brain
General
cyclin
phosphoprotein
Properties
SIZE: MW = 45-62 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G1/S
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
Database Correlations
OMIM 123838
UniProt P24863
Pfam PF00134
Entrez Gene 892
References
- Cordon-Cardo C.
Mutations of cell cycle regulators. Biological and clinical
implications for human neoplasia.
Am J Pathol. 1995 Sep;147(3):545-60. Review.
PMID: 7677168
- UniProt :accession P24863
Component-of
mediator complex (mediator of RNA polymerase 2 transcription)