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E3 ubiquitin-protein ligase CCNB1IP1; cyclin-B1-interacting protein 1; human enhancer of invasion 10; E3 ubiquitin-protein ligase HEI10 (CCNB1IP1, C14orf18, HEI10)
Function:
- E3 ubiquitin-protein ligase
- modulates cyclin B levels & participates in the regulation of cell cycle progression through the G2 phase
- overexpression causes delayed entry into mitosis
- protein modification; protein ubiquitination
- ubiquitinated; autoubiquitinated
- phosphorylated by CDK1 on Ser or Thr (in vitro)
- binds CCNB1 & UBE2L3
Structure: contains 1 RING-type Zn+2 finger
Compartment:
- nucleus, chromosome
- may associate with segregating chromosomes during metaphase & anaphase
Expression:
- expressed in heart > liver & kidney > placenta, brain & lung
General
nuclear protein
ring finger protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 277 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: RING-finger {4-51}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
coiled coil {127-182}
Database Correlations
OMIM 608249
UniProt Q9NPC3
Entrez Gene 57820
Kegg hsa:57820
References
UniProt :accession Q9NPC3