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cyclin
Sequential oscillations in the levels of the major cyclins (A, B & E) reflect mRNA levels.
Specific
CDK5 & ABL1 enzyme substrate 2 (interactor with CDK3 2, Ik3-2, CABLES2, C20orf150)
cyclin A
cyclin B
cyclin C (CCNC, hSRB11)
cyclin D
cyclin E
cyclin F (CCNF)
cyclin G
cyclin H (MO15-associated protein, CCNH)
cyclin K (CCNK, CPR4)
cyclin L
cyclin M
cyclin T (positive transcription elongation factor B, P-TEFB)
cyclin-I (CCNI)
cyclin-I2 (CCNI2)
cyclin-Y (cyclin fold protein 1, cyclin box protein 1, CCNY, C10orf9, CBCP1, CFP1)
cyclin-Y-like protein 1 (CCNYL1)
SRB11 protein
General
nuclear protein
PEST protein
Figures/Diagrams
Cyclins, CDK's & the Cell Cycle
Properties
SIZE: MW = 45-62 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G1
MOTIF: ubiquitination site (destruction box, D-box)
SITE: N-TERMINAL
FOR-BINDING-OF: ubiquitin
PEST region
cyclin box
FOR-BINDING-OF: cyclin-dependent kinase
References
- Hunt News & Views Nature 349:100 1991
- Morgan DO.
Principles of CDK regulation.
Nature. 1995 Mar 9;374(6518):131-4. Review.
PMID: 7877684
Component-of
molecular complex