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C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; G-protein coupled receptor bonzo; G-protein coupled receptor STRL33; CDw186; CD186 (CXCR6, BONZO, STRL33, TYMSTR)
Function:
- receptor for the C-X-C chemokine CXCL16
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression: expressed in lymphoid tissues & activated T cells
Pathology:
- used as a coreceptor by SIVs & by strains of HIV-2 & m-tropic HIV-1
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
CXC chemokine receptor
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 342 aa
MW = 39 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-32}
MOTIF: N-glycosylation site {N16}
transmembrane domain {33-59}
cytoplasmic loop {60-68}
transmembrane domain {69-89}
exoplasmic loop {90-103}
MOTIF: cysteine residue {C102}
MODIFICATION: cysteine residue {C180}
transmembrane domain {104-125}
cytoplasmic loop {126-143}
transmembrane domain {144-164}
exoplasmic loop {165-187}
MOTIF: cysteine residue {C180}
MODIFICATION: cysteine residue {C102}
transmembrane domain {188-215}
cytoplasmic loop {216-231}
transmembrane domain {232-259}
exoplasmic loop {260-275}
transmembrane domain {276-293}
cytoplasmic domain {294-342}
References
- UniProt :accession O00574
- Wikipedia; CXC chemokine receptors entry
http://en.wikipedia.org/wiki/CXC_chemokine_receptors
Databases & Figures
OMIM 605163
UniProt O00574
Pfam PF00001
Entrez Gene 10663
Kegg hsa:1066
CXC ligand and receptor binding