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C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; interferon-inducible protein 10 receptor; IP-10 receptor; CKR-L2; G protein-coupled receptor 9; CD183 (CXCR3, GPR9)
Function:
- receptor for CXCL9, CXCL10 & CXCL11
- mediates proliferation of human mesangial cells (HMC)
- isoform 2 is a receptor for CXCL4 & also mediates inhibitory activities of CXCL9, CXCL10 & CXCL11 on growth of human microvascular endothelial cells
- isoform 2 may play a role in angiogenesis
- isoform 3 mediates activity of CXCL11
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=3; exon skipping
Expression:
- isoform 1 & isoform 2 are mainly expressed in heart, kidney, liver & skeletal muscle
- isoform 1 is also expressed in placenta
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
CXC chemokine receptor
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 368 aa
MW = 41 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-53}
MOTIF: N-glycosylation site {N22}
N-glycosylation site {N32}
transmembrane domain {54-80}
cytoplasmic loop {81-89}
transmembrane domain {90-110}
exoplasmic loop {111-125}
MOTIF: cysteine residue {C124}
MODIFICATION: cysteine residue {C203}
transmembrane domain {126-147}
cytoplasmic loop {148-169}
transmembrane domain {170-189}
exoplasmic loop {190-212}
MOTIF: cysteine residue {C203}
MODIFICATION: cysteine residue {C124}
transmembrane domain {213-233}
cytoplasmic loop {234-255}
transmembrane domain {256-277}
exoplasmic loop {278-298}
transmembrane domain {299-321}
cytoplasmic domain {322-368}
Database Correlations
OMIM 300574
UniProt P49682
Pfam PF00001
Entrez Gene 2833
Kegg hsa:2833
References
- UniProt :accession P49682
- Wikipedia; CXC chemokine receptors entry
http://en.wikipedia.org/wiki/CXC_chemokine_receptors