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cannabinoid receptor 2; CB-2; CB2; CX5 (CNR2)
Function:
- role in cannabinoid-induced CNS effects through G-protein mediated inhibition of adenylate cyclase
- receptor for anandamide
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- not found in brain
- found in spleen
- found predominantly on immune system cells
Pathology:
- cannabinoids may slow progression of atherosclerosis through effects on CB2 receptors [2]
General
cannabinoid receptor
glycoprotein
Properties
SIZE: entity length = 360 aa
MW = 40 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-33}
MOTIF: N-glycosylation site {N11}
transmembrane domain {34-59}
cytoplasmic loop {60-71}
transmembrane domain {72-92}
exoplasmic loop {93-104}
transmembrane domain {105-129}
cytoplasmic loop {130-149}
transmembrane domain {150-172}
exoplasmic loop {173-188}
transmembrane domain {189-214}
cytoplasmic loop {215-246}
transmembrane domain {247-267}
exoplasmic loop {268-279}
transmembrane domain {280-301}
cytoplasmic domain {302-360}
Database Correlations
OMIM 605051
UniProt P34972
Pfam PF00001
Entrez Gene 1269
Kegg hsa:1269
References
- Munro et al
Molecular characterization of a peripheral receptor for
cannabinoids.
Nature 365:61 1993
PMID: 7689702
- Journal Watch 25(12):98, 2005
Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C,
Karsak M, Zimmer A, Frossard JL, Mach F.
Low dose oral cannabinoid therapy reduces progression of
atherosclerosis in mice.
Nature. 2005 Apr 7;434(7034):782-6.
Erratum in: Nature. 2005 May 26;435(7041):528.
Karsak, Meliha [added].
PMID: 15815632
- Roth MD.
Pharmacology: marijuana and your heart.
Nature. 2005 Apr 7;434(7034):708-9. No abstract available.
PMID: 15815611
- UniProt :accession P34972