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cutaneous pseudolymphoma
Etiology:
- drug eruption
- reactions to tattoo dyes
- reaction to jewelry (especially gold)
- insect bites
- folliculitis
- trauma
- infections
- Borrelia
- varicella-zoster virus
- molluscum contagiosum
- vaccinations
Epidemiology:
- uncommon
- female to male ratio is 2:1
- mean age of onset is 34 years
- 90% of patients are white
Pathology:
- inflammatory response that results in a lymphomatous-appearing but benign accumulation of inflammatory cells
- resemblance to lymphoma is usually most apparent histologically
- some cases may also mimic lymphoma clinically
Clinical manifestations:
- 2 patterns
a) B-cell pattern
- presentation with a cutaneous nodule or a group of discrete nodules, usually with minimal associated symptoms
b) T-cell pattern
- broader cutaneous patche
- often symptomatic
Laboratory:
- skin biopsy
- Borrelia burgdorferi serology
- Borrelia burgdorferi DNA
Differential diagnosis:
- contact dermatitis
- lymphomatoid papulosis
Complications:
- lymphoma
Management:
- not a lethal disorder
- removal of offending agent
- elective surgery:
- simple excision of the involved site can be curative in some cases
- surgical resection, cryosurgery, or local radiation therapy
- topical glucocorticoids, glucocorticoid injections & topical tacrolimus have been used
- observation for emergence of lymphoma
General
inflammation
skin disease (dermatologic disorder, dermatopathy, dermatosis)
References
- Ko CJ and Elston DM
eMedicine: Pseudolymphoma, Cutaneous
http://emedicine.medscape.com/article/1099188-overview