Search
cullin-associated NEDD8-dissociated protein 2; cullin-associated & neddylation-dissociated protein 2; epididymis tissue protein Li 169; TBP-interacting protein of 120 kD B; TBP-interacting protein 120B; p120 CAND2 (CAND2 KIAA0667 TIP120B)
Function:
1) assembly of ubiquitin ligase complexes
2) modulation of ubiquitination of target proteins
3) regulation of transcription (putative)
4) binds TBP, CNOT3, UBE3C
5) ubiquitinated & targeted for proteasomal degradation
Structure:
- belongs to the CAND family
- contains 23 HEAT repeats
Compartment: nucleus
Expression: expressed in epididymis (at protein level)
Related
cullin
NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)
General
HEAT repeat-containing protein (HEATR)
nuclear protein
Properties
SIZE: entity length = 1236 aa
MW = 135 kD
COMPARTMENT: cell nucleus
MOTIF: HEAT repeat {2-39}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
HEAT repeat {44-81}
HEAT repeat {83-119}
HEAT repeat {129-167}
HEAT repeat {171-208}
HEAT repeat {210-246}
HEAT repeat {254-291}
HEAT repeat {327-368}
HEAT repeat {372-409}
HEAT repeat {432-469}
serine-rich region {490-493}
MOTIF: serine residue (SEVERAL)
HEAT repeat {517-554}
HEAT repeat {565-604}
HEAT repeat {608-645}
HEAT repeat {648-685}
HEAT repeat {690-727}
HEAT repeat {731-770}
HEAT repeat {772-813}
HEAT repeat {857-894}
HEAT repeat {896-931}
HEAT repeat {933-966}
HEAT repeat {967-1003}
HEAT repeat {1007-1044}
HEAT repeat {1048-1084}
HEAT repeat {1105-1141}
HEAT repeat {1157-1194}
HEAT repeat {1204-1236}
Database Correlations
OMIM 610403
UniProt O75155
Pfam PF08623
Entrez Gene 23066
Kegg hsa:23066
References
UniProt :accession O75155