cullin-associated NEDD8-dissociated protein 1; cullin-associated & neddylation-dissociated protein 1; TBP-interacting protein of 120 kD A; TBP-interacting protein 120A; p120 CAND1 (CAND1, KIAA0829, TIP120, TIP120A)

Function: 1) enhances transcription from various types of promoters 2) regulatory protein that interferes with the assembly of SCF ubiquitin ligase complex (SKP1-CUL1-F-box protein complex) - down-regulates ubiquitination of target proteins 3) prevents neddylation of CUL1 by physically blocking access to neddylation site 4) disrupts interactions between CUL1 & SKP1A & between CUL1 & F-box proteins 5) binds TBP 6) bomponent of complex that contains CUL1 & RBX1 7) binds unneddylated CUL1, but cannot bind CUL1 once neddylated 8) binds CUL2, CUL3, CUL4A, CUL4B, CUL5 Structure: - belongs to the CAND family - contains 27 HEAT repeats Compartment: nucleus Alternative splicing: named isoforms=3

Related

cullin NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

General

HEAT repeat-containing protein (HEATR) nuclear protein phosphoprotein

Properties

SIZE: entity length = 1230 aa MW = 136 kD COMPARTMENT: cell nucleus MOTIF: HEAT repeat {2-39} acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl HEAT repeat {44-81} HEAT repeat {83-119} HEAT repeat {131-165} HEAT repeat {171-208} HEAT repeat {210-247} HEAT repeat {248-282} HEAT repeat {289-366} MOTIF: Ser phosphorylation site {S335} Ser phosphorylation site {S340} HEAT repeat {370-407} HEAT repeat {424-467} HEAT repeat {471-510} HEAT repeat {515-552} HEAT repeat {563-602} HEAT repeat {606-643} MOTIF: Thr phosphorylation site {T624} HEAT repeat {646-683} HEAT repeat {688-725} HEAT repeat {729-768} HEAT repeat {770-808} HEAT repeat {809-845} HEAT repeat {852-889} HEAT repeat {890-927} HEAT repeat {928-960} HEAT repeat {961-998} HEAT repeat {1002-1039} HEAT repeat {1043-1097} HEAT repeat {1099-1133} HEAT repeat {1140-1189}

Database Correlations

OMIM 607727 UniProt Q86VP6 Pfam PF08623 Entrez Gene 55832 Kegg hsa:55832

References

UniProt :accession Q86VP6