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Cullin-7; CUL-7 (CUL7, KIAA0076)
Function:
1) component of a probable SCF-like E3 ubiquitin ligase
- ubiquitin conjugation, 3rd step
2) degradation of proteins involved in endothelial proliferation &/or differentiation
3) does not seem to promote polyubiquitination & proteosomal degradation of TP53
4) in vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity
5) protein modification; protein ubiquitination
6) component of SCF-like complex (CUL7-RBX1-SKP1-FBXW8 complex)
7) interacts with a complex of SKP1 & FBXW8, but not with SKP1 alone
8) interacts with CUL9
9) interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or TP53
10) interacts with TP53; the interaction preferentially involves tetrameric & dimeric TP53
11) the CUL7-CUL9 heterodimer seems to interact specifically with TP53
12) interacts with CUL1; the interactions seems to be mediated by FBXW8 (putative)
Structure:
- belongs to the cullin family
- contains 1 DOC domain
Compartment: cytoplasm
Expression:
- expressed in fetal kidney, skeletal muscle, fetal brain, adult pancreas, kidney, placenta, heart
- expressed in trophoblasts, lymphoblasts, osteoblasts, chondrocytes & skin fibroblasts
Pathology:
- defects in CUL7 are the cause of 3M syndrome
General
cell surface receptor
cullin
phosphoprotein
Properties
SIZE: entity length = 1698 aa
MW = 191 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S329}
Ser phosphorylation site {S339}
TP53 interaction {360-460}
DOC {814-993}
Database Correlations
OMIM correlations
UniProt Q14999
PFAM correlations
Entrez Gene 9820
References
- UniProt :accession Q14999
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/CUL7
Component-of
CUL7-RBX1-SKP1-FBXW8 complex (SCF-like complex)