Cullin-5; CUL-5; vasopressin-activated Ca+2-mobilizing receptor 1; VACM-1 (CUL5, VACM1)

Function: - core component of multiple SCF-like ECS complex(es) (elongin-Cullin 2/5-SOCS-box protein complex), E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination & subsequent proteasomal degradation of target proteins - as a scaffold protein may contribute to catalysis through positioning of substrate & ubiquitin-conjugating enzyme - functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component - ECS(SOCS1) seems to direct ubiquitination of Jak2 - seems to be involved poteosomal degradation of p53/TP53 - stimulated by adenovirus E1B-55 kD protein - may form a cell surface vasopressin receptor - protein modification; protein ubiquitination - neddylated. deneddylated via its interaction with the COP9 signalosome (CSN complex) (putative) - component of ECS(LRRC41) complex - component of ECS(SOCS1) complex - component of ECS(WSB1) complex - component of ECS(SOCS3) complex - component of ECS(SPSB1) complex - component of ECS(SPSB2) complex - component of ECS(SPSB4) complex - component of ECS(RAB40C) complex - may also form complexes containing CUL5, elongin BC complex (TCEB1 & TCEB2), RBX1 & TCEB3 - may also form complexes containing CUL5, elongin BC (TCEB1 & TCEB2), RBX1 & VHL - the substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen & E4-orf6 - interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 & RAB40C - interacts with ASB1, ASB2, ASB6, ASB7 & ASB12 Structure: belongs to the cullin family

General

cell surface receptor cullin phosphoprotein

Properties

SIZE: entity length = 780 aa MW = 91 kD COMPARTMENT: plasma membrane MOTIF: Thr phosphorylation site {T210}

Database Correlations

OMIM 601741 UniProt Q93034 PFAM correlations Entrez Gene 8065 Kegg hsa:8065

References

UniProt :accession Q93034