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CUL7-RBX1-SKP1-FBXW8 complex (SCF-like complex)
Structure:
- consists of at least CUL7, SKP1, RBX1, FBXW8
General
molecular complex
Properties
SUBUNITS: Cullin-7
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S329}
Ser phosphorylation site {S339}
TP53 interaction {360-460}
DOC {814-993}
S-phase kinase-associated protein 1
MOTIF: F-box interaction {104-163}
RING-box protein 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S11}
Zn+2-binding site
SITE: 42-42
Zn+2-binding site
SITE: 45-45
RING-finger {53-98}
MOTIF: Zn+2-binding site
SITE: 53-53
Zn+2-binding site
SITE: 56-56
Zn+2-binding site
SITE: 68-68
Zn+2-binding site
SITE: 75-75
Zn+2-binding site
SITE: 77-77
Zn+2-binding site
SITE: 80-80
Zn+2-binding site
SITE: 82-82
Zn+2-binding site
SITE: 83-83
Zn+2-binding site
SITE: 94-94
Zn+2-binding site
SITE: 97-97
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
F-box/WD repeat-containing protein 8
MOTIF: Ser phosphorylation site {S85}
F-box domain {113-159}
WD repeat {197-245}
WD repeat {254-294}
WD repeat {297-336}
WD repeat {430-470}
WD repeat {473-510}
References
UniProt :accession Q9BZF9
Components
Cullin-7; CUL-7 (CUL7, KIAA0076)
F-box/WD repeat-containing protein 8; F-box & WD-40 domain-containing protein 8; F-box only protein 29 (FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6)
RING-box protein 1; Rbx1; regulator of cullins 1; RING finger protein 75; protein ZYP (RBX1 RNF75 ROC1)
S-phase kinase-associated protein 1; cyclin-A/CDK2-associated protein p19; p19skp1; p19A; RNA polymerase II elongation factor-like protein; organ of corti protein 2; OCP-2; organ of corti protein II; OCP-II; transcription elongation factor B; SIII (SKP1, EMC19, OCP2, SKP1A, TCEB1L)