CUL3/KLHL12 ubiquitin protein E3 ligase complex

Function: - interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A Structure: - consists of: CUL3, KLHL12

General

molecular complex E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

MOTIF: active site SUBUNITS: Cullin-3 COMPARTMENT: cell nucleus golgi MOTIF: Tyr phosphorylation site {Y58} Ser phosphorylation site {S450} Ser phosphorylation site {S737} Kelch-like protein 12 COMPARTMENT: cytoplasm MOTIF: BTB domain {33-100} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 kelch repeat {282-329} kelch repeat {331-379} kelch repeat {380-426} interaction with DVL3 {405-568} MOTIF: kelch repeat {427-473} kelch repeat {475-520} kelch repeat {522-567}

References

UniProt :accession Q53G59

Components

Cullin-3; CUL-3 (CUL3 KIAA0617) Kelch-like protein 12 (CUL3-interacting protein 1, KLHL12, C3IP1)