CUB domain-containing protein 1; membrane glycoprotein gp140; subtractive immunization M plus HEp3-associated 135 kD protein; SIMA135; transmembrane & associated with src kinases; CD318 (CDCP1, TRASK, UNQ2486/PRO5773)

Function: 1) cell adhesion 2) cell matrix association 3) tumor progression & metastasis 4) interacts with N-cadherin, P-cadherin, syndecan-1, syndecan-4, serine protease ST14, SRC, protein kinase C gamma 5) phosphorylated on Tyr by SRC, YES, protein kinase C gamma, suramin; phosphorylated in response to dissociation of integrin alpha-6, beta-4 from laminin-5 Compartment: - cell membrane - shedding may lead to a soluble peptide Alternative splicing: named isoforms=3 Expression: - highly expressed in mitotic cells - low expression during interphase - expressed in skeletal muscle, colon > kidney, small intestine, placenta, lung - expressed in human tumor cell lines, colorectal cancer, breast carcinoma, lung cancer

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen CUB domain-containing protein glycoprotein phosphoprotein

Properties

SIZE: MW = 93 kD entity length = 836 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-29} N-glycosylation site {N39} N-glycosylation site {N122} N-glycosylation site {N180} N-glycosylation site {N205} N-glycosylation site {N270} N-glycosylation site {N310} proteolytic site {368-369} N-glycosylation site {N386} CUB domain {417-544} MOTIF: cysteine residue {C476} MODIFICATION: cysteine residue {C499} cysteine residue {C499} MODIFICATION: cysteine residue {C476} transmembrane domain {668-688} Tyr phosphorylation site {Y734}

Database Correlations

OMIM 611735 UniProt Q9H5V8 Entrez Gene 64866 Kegg hsa:64866

References

UniProt :accession Q9H5V8