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cubam complex
Structure:
- consists of: CUBN, AMN
General
molecular complex
Properties
SUBUNITS: cubilin
COMPARTMENT: lysosome
endosome
MOTIF: signal sequence {1-23}
MOTIF: N-glycosylation site {N3}
proteolytic site {35-36}
N-glycosylation site {N105}
EGF domain {132-168} (7)
MOTIF: cysteine residue {C136}
MODIFICATION: cysteine residue {C147}
cysteine residue {C141}
MODIFICATION: cysteine residue {C156}
cysteine residue {C147}
MODIFICATION: cysteine residue {C136}
cysteine residue {C156}
MODIFICATION: cysteine residue {C141}
cysteine residue {C158}
MODIFICATION: cysteine residue {C167}
cysteine residue {C167}
MODIFICATION: cysteine residue {C158}
CUB domain {474-586} (27)
MOTIF: cysteine residue {C474}
MODIFICATION: cysteine residue {C500}
N-glycosylation site {N482}
cysteine residue {C500}
MODIFICATION: cysteine residue {C474}
cysteine residue {C527}
MODIFICATION: cysteine residue {C549}
cysteine residue {C549}
MODIFICATION: cysteine residue {C527}
amnionless protein
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
N-glycosylation site {N35}
VWFC domain {202-254}
transmembrane domain {358-378}
References
UniProt :accession O60494
Components
amnionless protein (AMN)
cubilin (intrinsic factor-cobalamin receptor, intrinsic factor-vitamin B12 receptor, 460 kD receptor, intestinal intrinsic factor receptor, CUBN, IFCR)