cytidine triphosphate [CTP] synthase; UTP-NH3 ligase (CTPS)

Function: 1) catalyzes ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen 2) rate-limiting enzyme in synthesis of cytosine nucleotides 3) nucleotide biosynthesis, CTP biosynthesis, CTP from UDP: step 2 [final step] ATP + UTP + NH₃ ADP + phosphate + CTP Structure: - belongs to the CTP synthase family - contains 1 type-1 glutamine amidotransferase domain

Specific

CTP synthase 1; CTP synthetase 1; UTP-ammonia ligase 1 (CTPS1) CTP synthase 2; UTP-ammonia ligase 2; CTP synthetase 2 (CTPS2)

Properties

MOTIF: active site

References

UniProt :accession P17812, Q9NRF8