Crumbs protein homolog 3 (CRB3)

Function: - role in the establishment of cell polarity in mammalian epithelial cells - regulates the morphogenesis of tight junctions - interacts with MPP5, PARD6A & INADL Structure: - PDZ-binding motif is involved in the interactions with PARD6A & MPP5 Compartment: - apical cell membrane, cell junction, tight junction - localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells Alternative splicing: named isoforms=2 Expression: - preferentially expressed in epithelial tissues - expressed at high levels in lung, kidney, retina, colon & mammary glands - expressed at moderate levels in liver, spleen, pancreas, placenta & prostate

General

glycoprotein membrane protein

Properties

SIZE: MW = 13 kD entity length = 120 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} N-glycosylation site {N36} transmembrane domain {60-80} PDZ recognition motif NAME: PDZ recognition motif SITE: 117-120 FOR-BINDING-VIA: PDZ domain

References

UniProt :accession Q9BUF7