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CRSP complex

Function: - transcriptional coactivation Structure: - components: - PPARBP, CRSP1, CRSP2, CRSP3, CRSP4, CRSP5, CRSP6, CRSP7, CRSP8 & CRSP9

Related

activator-recruited cofactor (ARC)/DRIP thyroid hormone receptor associated protein complex (TRAP)

General

molecular complex

Properties

COMPARTMENT: cell nucleus SUBUNITS: mediator of RNA polymerase II transcription subunit 1 COMPARTMENT: cell nucleus MOTIF: Mediator/THRA interaction {1-670} MOTIF: ESR1 interaction {16-590} Ser phosphorylation site {S18} Mediator interaction {108-212} Mediator interaction {215-390} THRA interaction {405-644} VDR interaction {542-789} MOTIF: LXXLL motif 1 {604-608} PPARGC1A/THRA interaction {622-701} GATA1 interaction {637-716} LXXLL motif 2 {645-649} ESR1 interaction {656-1066} MOTIF: Ser phosphorylation site {S664} Ser phosphorylation site {S770} Ser phosphorylation site {S771} Ser phosphorylation site {S772} Ser phosphorylation site {S774} Ser phosphorylation site {S795} Thr phosphorylation site {T805} Ser phosphorylation site {S953} Thr phosphorylation site {T1032} Ser phosphorylation site {S1049} Thr phosphorylation site {T1051} Thr phosphorylation site {T1057} serine-rich region {1078-1482} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S1134} Ser phosphorylation site {S1155} Ser phosphorylation site {S1207} Thr phosphorylation site {T1215} Ser phosphorylation site {S1223} Ser phosphorylation site {S1232} TP53 interaction {1249-1421} Ser phosphorylation site {S1252} Ser phosphorylation site {S1403} Ser phosphorylation site {S1433} Ser phosphorylation site {S1439} Thr phosphorylation site {T1440} Thr phosphorylation site {T1457} Ser phosphorylation site {S1463} Ser phosphorylation site {S1479} Ser phosphorylation site {S1481} Ser phosphorylation site {S1482} lysine-rich region {1496-1529} MOTIF: lysine residue (SEVERAL) mediator of RNA polymerase II transcription subunit 1 COMPARTMENT: cell nucleus MOTIF: Mediator/THRA interaction {1-670} MOTIF: ESR1 interaction {16-590} Ser phosphorylation site {S18} Mediator interaction {108-212} Mediator interaction {215-390} THRA interaction {405-644} VDR interaction {542-789} MOTIF: LXXLL motif 1 {604-608} PPARGC1A/THRA interaction {622-701} GATA1 interaction {637-716} LXXLL motif 2 {645-649} ESR1 interaction {656-1066} MOTIF: Ser phosphorylation site {S664} Ser phosphorylation site {S770} Ser phosphorylation site {S771} Ser phosphorylation site {S772} Ser phosphorylation site {S774} Ser phosphorylation site {S795} Thr phosphorylation site {T805} Ser phosphorylation site {S953} Thr phosphorylation site {T1032} Ser phosphorylation site {S1049} Thr phosphorylation site {T1051} Thr phosphorylation site {T1057} serine-rich region {1078-1482} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S1134} Ser phosphorylation site {S1155} Ser phosphorylation site {S1207} Thr phosphorylation site {T1215} Ser phosphorylation site {S1223} Ser phosphorylation site {S1232} TP53 interaction {1249-1421} Ser phosphorylation site {S1252} Ser phosphorylation site {S1403} Ser phosphorylation site {S1433} Ser phosphorylation site {S1439} Thr phosphorylation site {T1440} Thr phosphorylation site {T1457} Ser phosphorylation site {S1463} Ser phosphorylation site {S1479} Ser phosphorylation site {S1481} Ser phosphorylation site {S1482} lysine-rich region {1496-1529} MOTIF: lysine residue (SEVERAL) mediator of RNA polymerase II transcription subunit 14 COMPARTMENT: cell nucleus MOTIF: LXXLL motif 1 {69-73} STAT2 interaction {188-566} SREBF1 interaction {500-824} MOTIF: Ser phosphorylation site {S617} Ser phosphorylation site {S986} proline-rich region SITE: 1002-1165 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1112} Ser phosphorylation site {S1119} Ser phosphorylation site {S1128} Ser phosphorylation site {S1133} Ser phosphorylation site {S1136} Ser phosphorylation site {S1142} Ser phosphorylation site {S1144} LXXLL motif 2 {1182-1186} mediator of RNA polymerase II transcription subunit 23 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S1352} mediator of RNA polymerase II transcription subunit 24 COMPARTMENT: cell nucleus MOTIF: LXXLL motif 1 {128-132} LXXLL motif 2 {344-348} LXXLL motif 3 {448-452} LXXLL motif 4 {557-561} LXXLL motif 5 {788-792} LXXLL motif 6 {857-861} Ser phosphorylation site {S862} Ser phosphorylation site {S873} CRSP5 mediator of RNA polymerase II transcription subunit 17 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S37} Ser phosphorylation site {S50} Ser phosphorylation site {S53} Ser phosphorylation site {S55} Ser phosphorylation site {S75} Ser phosphorylation site {S76} Thr phosphorylation site {T143} Ser phosphorylation site {S185} mediator of RNA polymerase II transcription subunit 26 COMPARTMENT: cell nucleus MOTIF: TFIIS N-terminal {10-87} proline-rich region SITE: 228-325 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S314} Ser phosphorylation site {S337} Ser phosphorylation site {S361} Ser phosphorylation site {S447} CRSP complex subunit 8 COMPARTMENT: cell nucleus mediator of RNA polymerase II transcription subunit 7 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S194}

References

UniProt :accession Q15813

Components

CRSP complex subunit 8; cofactor required for Sp1 transcriptional activation subunit 8; transcriptional coactivator; p37 TRAP/SMCC/PC2 subunit (CRSP8, CRSP34, MED27) mediator of RNA polymerase II transcription subunit 14; activator-recruited cofactor 150 kD component; ARC150; cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; mediator complex subunit 14; RGR1 homolog; hRGR1; thyroid hormone receptor-associated protein complex 170 kD component; trap170; transcriptional coactivator CRSP150; vitamin D3 receptor-interacting protein complex 150 kD component; DRIP150 (MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170) mediator of RNA polymerase II transcription subunit 17; activator-recruited cofactor 77 kD component; ARC77; cofactor required for Sp1 transcriptional activation subunit 6; CRSP complex subunit 6; mediator complex subunit 17; thyroid hormone receptor-associated protein complex 80 kD component; trap80; transcriptional coactivator CRSP77; vitamin D3 receptor-interacting protein complex 80 kD component; DRIP80 (MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80) mediator of RNA polymerase II transcription subunit 1; activator-recruited cofactor 205 kD component; ARC205; mediator complex subunit 1; peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; thyroid hormone receptor-associated protein complex 220 kD component; trap220; thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; vitamin D receptor-interacting protein complex component DRIP205; p53 regulatory protein RB18A (MED1, ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2) mediator of RNA polymerase II transcription subunit 23; activator-recruited cofactor 130 kD component; ARC130; cofactor required for Sp1 transcriptional activation subunit 3; CRSP complex subunit 3; mediator complex subunit 23; protein sur-2 homolog; hSur-2; transcriptional coactivator CRSP130; vitamin D3 receptor-interacting protein complex 130 kD component; DRIP130 (MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2) mediator of RNA polymerase II transcription subunit 24; activator-recruited cofactor 100 kD component; ARC100; cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; mediator complex subunit 24; thyroid hormone receptor-associated protein 4; thyroid hormone receptor-associated protein complex 100 kD component; trap100; hTRAP100; vitamin D3 receptor-interacting protein complex 100 kD component; DRIP100 (MED24, ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100) mediator of RNA polymerase II transcription subunit 26; activator-recruited cofactor 70 kD component; ARC70; cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; mediator complex subunit 26; transcriptional coactivator CRSP70 (MED26, ARC70, CRSP7) mediator of RNA polymerase II transcription subunit 7; hMED7; activator-recruited cofactor 34 kD component; ARC34; cofactor required for Sp1 transcriptional activation subunit 9; CRSP complex subunit 9; mediator complex subunit 7; RNA polymerase transcriptional regulation mediator subunit 7 homolog; transcriptional coactivator CRSP33 (MED7 ARC34 CRSP9)