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CRLF1/CLCF1 complex
Function:
- ligand for the ciliary neurotrophic factor receptor (CNTFR)
Structure: subunits: CRLF1, CLCF1
Pathology:
- defects in either subunit results in cold-induced sweating syndrome
General
molecular complex
Properties
SUBUNITS: cytokine receptor-like factor 1
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-37}
immunoglobulin superfamily domain {38-131}
MOTIF: N-glycosylation site {N92}
N-glycosylation site {N104}
fibronectin type III domain or F3 module {134-229}
MOTIF: N-glycosylation site {N140}
cysteine residue {C143}
MODIFICATION: cysteine residue {C153}
cysteine residue {C153}
MODIFICATION: cysteine residue {C143}
N-glycosylation site {N168}
cysteine residue {C184}
MODIFICATION: cysteine residue {C195}
cysteine residue {C195}
MODIFICATION: cysteine residue {C184}
Ser phosphorylation site {S219}
fibronectin type III domain or F3 module {234-334}
MOTIF: N-glycosylation site {N292}
WSXWS motif {327-331}
N-glycosylation site {N382}
cardiotrophin-like cytokine factor
COMPARTMENT: extracellular compartment
MOTIF: glycosylation site
References
UniProt :accession O75462, Q9UBD9
Components
cardiotrophin-like cytokine factor 1 (B cell-stimulating factor 3, BSF-3, novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1)
cytokine receptor-like factor 1 (cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1, ZCYTOR5, UNQ288/PRO327)