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critical illness cognitive impairment (post-ICU cognitive impairment)

Etiology: - critical illness, especially - sepsis - acute respiratory distress syndrome - risk factors - age - duration of mechanical ventilation - glycemic control: hyperglycemia, hypoglycemia - duration of delirium [3] - duration of coma apparently not a factor [3] - this may not be reproducible - benzodiazepine use apparently not a factor [3] - other studies would suggest interaction of long-term benzodiazepine use & cognitive impairment in the elderly Epidemiology: - occurs in up to 75% of critically ill patients Clinical manifestations: - appears to be acquired dementia [2,3]

Related

critical illness weakness; critical illness neuromyopathy

General

cognitive impairment critical illness neuropsychiatric impairment (post-ICU neuropsychiatric impairment)

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018.
  2. Jackson JC, Mitchell N, Hopkins RO. Cognitive functioning, mental health, and quality of life in ICU survivors: an overview. Anesthesiol Clin. 2011 Dec;29(4):751-64 PMID: 22078921
  3. Pandharipande PP et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013 Oct 3; 369:1306 PMID: 24088092