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diagnostic criteria for systemic lupus erythematosus (SLE)

Diagnostic criteria: Criteria for SLE (4 must be present for definitive diagnosis): 1) malar rash 2) discoid lupus, discoid rash 3) oral ulcers or nasal ulcers 4) arthritis (non-erosive arthritis of >= 2 peripheral joints) 5) photosensitivity 6) serositis: pleurisy, or pericarditis 7) neurologic disorder: seizures or psychosis 8) renal disease a) proteinuria > 500 mg/day or 3+ on dipstick, or b) cellular casts 9) hematologic disorder a) hemolytic anemia with reticulocytosis, or b) leukopenia (< 4000/mm3), or c) lymphopenia (< 1500/mm3) d) thrombocytopenia (< 100,000/mm3) 10) immunologic disorder a) anti double-stranded DNA (anti-dsDNA), or b) anti-Smith (Sm) antigen, or d) anti-phospholipid antibody - false positive test for syphilis 11) antinuclear antibody (ANA) at titer of >= 1:80 must be present [2] European League Against Rheumatism/American College of Rheumatology classification criteria [3]

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systemic lupus erythematosus

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References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1014
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 16, 17. American College of Physicians, Philadelphia 1998, 2006, 2009, 2012, 2015 - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  3. Aringer M et al. European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance. Ann Rheum Dis 2021 Feb 10; 80:775. PMID: 33568386 https://ard.bmj.com/content/80/6/775 - Aringer M et al 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis 2019. Sep;78(9):1151-1159 PMID: 31383717 Review. https://ard.bmj.com/content/78/9/1151