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diagnostic criteria for Sjogren's syndrome
Diagnostic criteria:
1) ocular signs & symptoms
a) dry eyes every day for more than 3 months
b) recurrent sensation of sand or gravel in the eyes or use of tear substitutes more than 3 times/day
c) positive Schirmer's I test or rose Bengal score of >= 4 (Bijsterveld's scoring)
2) oral symptoms
a) daily feeling of dry mouth for more than 3 months
b) recurrent or persistently swollen salivary glands, or use of liquids to aid in swallowing dry foods
3) histopathology
- focus score 1 in minor salivary gland biopsy
4) salivary gland involvement by
a) salivary scintigraphy, or
b) parotid sialography, or
c) salivary flow (=< 1.5 mL in 15 min)
5) autoantibodies to:
a) anti-SSA/Ro Ab, or
b) anti-SSB/La Ab, or
c) antinuclear antibodies (ANA)*, or
d) rheumatoid factor (RF)*
* not included as criteria in [2[
Exclusion criteria:
1) previous head & neck radiation
2) hepatitis C
3) AIDS
4) pre-existing lymphoma
5) sarcoidosis
6) graft-vs-host disease
7) use of anticholinergic agent(s)
Related
Sjogren's syndrome (autoimmune epitheliitis)
General
criteria
References
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1903
- Medical Knowledge Self Assessment Program (MKSAP) 16
American College of Physicians, Philadelphia 2012