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criteria for diagnosis of polycythemia vera

Diagnostic criteria: 1) elevated red cell mass (erythrocytosis) 2) normal arterial oxygen saturation 3) splenomegaly 4) in the absence of splenomegaly, leukocytosis & thrombocytosis 5) plasma erythropoietin level < 4 mU/mL 6) JAK2 V617F mutation [2,3]* *proposed diagnostic criteria would allow diagnosis of JAK2 V617F mutation-associated disorders without a bone marrow biopsy [2]

Related

polycythemia rubra vera (PRV, PV, erythremia)

General

criteria

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 680
  2. Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
  3. Vainchenker W and Constantinescu SN Hematology Am Soc Hematol Educ Program. 2005:195-200. A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases PMID: 16304380 http://asheducationbook.hematologylibrary.org/cgi/content/full/2005/1/195