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corticotropin-releasing factor-binding protein; CRF-BP; CRF-binding protein; corticotropin-releasing hormone-binding protein; CRH-BP (CRHBP CRFBP)
Function:
- binds CRF & inactivates it
- may prevent inappropriate pituitary-adrenal stimulation during pregnancy
Structure: belongs to the CRF-binding protein family
Compartment: secreted
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 322 aa
MW = 36 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
cysteine residue {C60}
MODIFICATION: cysteine residue {C81}
cysteine residue {C81}
MODIFICATION: cysteine residue {C60}
cysteine residue {C104}
MODIFICATION: cysteine residue {C141}
cysteine residue {C141}
MODIFICATION: cysteine residue {C104}
cysteine residue {C183}
MODIFICATION: cysteine residue {C205}
N-glycosylation site {N204}
cysteine residue {C205}
MODIFICATION: cysteine residue {C183}
cysteine residue {C237}
MODIFICATION: cysteine residue {C264}
cysteine residue {C264}
MODIFICATION: cysteine residue {C237}
cysteine residue {C277}
MODIFICATION: cysteine residue {C318}
cysteine residue {C318}
MODIFICATION: cysteine residue {C277}
Database Correlations
OMIM 122559
UniProt P24387
Pfam PF05428
Entrez Gene 1393
Kegg hsa:1393
References
UniProt :accession P24387