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CREB-regulated transcription coactivator 1 (transducer of regulated cAMP response element-binding protein 1, transducer of CREB protein 1, mucoepidermoid carcinoma translocated protein 1, CRTC1, KIAA0616, MECT1, TORC1, WAMTP1)
Function:
1) transcriptional coactivator for CREB1
2) does not appear to modulate CREB1 DNA-binding activity
3) enhances the interaction of CREB1 with TAF4
4) interacts through its N-terminal region with the bZIP domain of CREB1
5) binds to CREB1 as a homotetramer
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in a restricted set of tissues including fetal brain & liver, adult heart, skeletal muscle, liver, salivary gland.
Pathology:
- chromosomal translocation t(11;19)(q21;p13) involving CRTC1 with MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors & clear cell hidradenomas
General
CREB-regulated transcription coactivator (transducer of regulated cAMP response element-binding protein, transducer of CREB protein, CRTC)
Properties
SIZE: MW = 67 kD
entity length = 634 aa
COMPARTMENT: cell nucleus
MOTIF: breakpoint {42-43}
Database Correlations
OMIM 607536
UniProt Q6UUV9
References
- UniProt :accession Q6UUV9
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/CRTC1ID471ch19p13.html