CRAL-TRIO lipid binding domain

Structurally conserved domain of about 170 amino acids, forming a hydrophobic lipid binding pocket. The pocket floor consists of 6 beta-strands & the sides are formed by alpha-helices. It is found in: 1) GTPase-activating proteins 2) guanine nucleotide exchange factors 3) hydrophobic ligand binding proteins a) retinaldehyde-binding protein b) alpha-tocopherol-binding protein

General

peptide motif domain

References

prosite :accession PS50191